Journal:
Article Title: Leukotriene B 4 Augments Neutrophil Phagocytosis of Klebsiella pneumoniae
doi: 10.1128/IAI.69.4.2011-2016.2001
Figure Lengend Snippet: Effect of endogenous LT synthesis inhibition on PMN phagocytosis of opsonized K. pneumoniae. Human PMNs were pretreated in the absence (control) or presence of zileuton (10 μM) or MK-886 (1 μM) for 15 min prior to the addition of K. pneumoniae opsonized with 1% immune serum. The phagocytic index of the control was 93 ± 23. Data are presented as the mean ± SE (n = 5). ∗, P < 0.05 with respect to the control, using a paired t test.
Article Snippet: In some experiments, PMNs were pretreated for 15 min with the 5-LO enzyme inhibitor zileuton (10 μM; Abbott Laboratories, Chicago, Ill.), the 5-LO activating protein inhibitor MK-886 (1 μM; Merck-Frosst, Montreal, Quebec, Canada), the cysteinyl-LT receptor antagonist LY171883 (1 μM), or the LTB 4 receptor antagonist LY292476 (1 μM) (the latter two from Eli Lilly, Indianapolis, Ind.), each diluted in Hanks balanced salt solution.
Techniques: Inhibition